Tohuan Steve Chen

c/o Armistice Capital LLC

510 Madison Avenue

7^th Floor

New York, NY 10022

Telephone Number: 212-231-4930

(Name, Address and Telephone Number of Person Authorized to Receive

Notices and Communications)

The name of the issuer is Aytu Bioscience, Inc., a Delaware corporation (the "Issuer"). The address of the Issuer's principal executive offices is 373 Inverness Parkway, Suite 206, Englewood, Colorado 80112. This Schedule 13D relates to the Issuer's Common Stock, par value $.0001 (the "Shares").

Armistice Capital is an investment adviser registered with the Securities and Exchange Commission (the “SEC”) that is principally engaged in the business of providing investment management services to private investment vehicles, including the Master Fund. The principal business address of Armistice Capital is 510 Madison Avenue, 7^th Floor, New York, New York 10022.

The Master Fund is principally engaged in the business of investing in securities. The principal business address of the Master Fund is c/o dms Corporate Services Ltd., 20 Genesis Close, P.O. Box 314, Grand Cayman KY1-1104, Cayman Islands. The board of directors of the Master Fund consists of Steven Boyd, Kevin A. Phillip and Gregory S. Bennett.

Steven Boyd is the managing member of Armistice Capital and a director of the Master Fund. Mr. Boyd’s business address is 510 Madison Avenue, 7^th Floor, New York, New York 10022.

On November 29, 2018, the Issuer issued to the Master Fund a secured promissory note in the principal amount of $5,000,000 (the “Promissory Note”). The Promissory Note was secured by the future revenue stream from the products licensed to Issuer under the License, Development, Manufacturing and Supply Agreement between the Issuer and TRIS Pharma, Inc. The Promissory Note carried an annual interest rate of 8% and had a three-year term. On February 5, 2019, the Issuer and the Master Fund entered in to an exchange agreement (the “Exchange Agreement”) pursuant to which the Master Fund agreed to exchange the Promissory Note for: (i) 3,120,064 Shares (the “New Shares”); (ii) 2,751,148 shares of the Issuer’s Series E Convertible Preferred Stock (the “Series E Preferred Stock”); and (iii) a Common Stock Purchase Warrant (the “Warrant”, and collectively with the New Shares and the Series E Preferred Stock, the “Exchange Securities”). Upon issuance of the Exchange Securities, the Master Fund will cancel the Promissory Note and all principal and interest owed thereunder. Each share of the Series E Preferred Stock has a stated value of $0.88 (the “Stated Value”), subject to increase pursuant to the terms of the Issuer’s Certificate of Designation of Preferences, Rights and Limitations of Series E Preferred Stock (the “Series E COD”). The Series E Preferred Stock is convertible into Shares at the option of the holder at any time after the issue date into that number of Shares determined by dividing the Stated Value by the conversion price of $0.88, which is subject to adjustment pursuant to the terms of the Series E COD; provided, however, that each holder is subject to a blocker provision that prevents it from converting its Series E Preferred Stock if it would be more than a 40% beneficial owner of the Shares following such conversion. The Warrant permits the Master Fund to purchase 4,403,409 Shares at an exercise price of $1.00 per Share, which is subject to adjustment pursuant to the terms of the Warrant; provided, however, that each holder is subject to a subject to a blocker provision that prevents it from exercising the warrants if it would be more than a 40% beneficial owner of the Shares following such exercise. The Warrant expires on the five-year anniversary of the date of its issuance. The obligations of the Issuer and the Master Fund to consummate the transactions contemplated by the Exchange Agreement are subject to the Issuer’s stockholders approving the issuance of the Exchange Securities. The Issuer also agreed in the Exchange Agreement to register the New Shares and the Shares underlying the Series E Preferred Stock and the Warrant within 180 days of the Exchange Agreement’s closing date.

On February 5, 2019, the Issuer and the Master Fund also entered into a waiver of blocker agreement in respect of the Issuer’s Series C Convertible Preferred Stock (the “Series C Preferred Stock”) held by the Master Fund as of such date (the “Waiver”). Pursuant to the Waiver, the Issuer and the Master Fund waived the beneficial ownership limitation contained in the Issuer’s Certificate of Designation of Preferences, Rights and Limitations of Series C Preferred Stock (the “Series C COD”), solely with respect to the Master Fund. After executing the Waiver, on February 5, 2019, the Master Fund converted all of its 1,900,000 shares of Series C Preferred Stock into 1,900,000 Shares at the conversion price of $1.50 per Share.

The foregoing was a summary of certain material terms of the: (i) Promissory Note; (ii) Exchange Agreement; (iii) Series E COD; (iv) Warrant; (v) Waiver; and (vi) Series C COD. The foregoing descriptions are not, and do not purport to be, complete and are qualified in their entirety by reference to the full text of those documents, which have been filed as Exhibits B, C, D, E, F and G, respectively, and are incorporated herein by reference.

The Issuer also announced in a Form 8-K filed with the SEC by the Issuer on December 4, 2018 that it anticipates that its board of directors (the “Board”) will elect Mr. Boyd to fill a current vacancy on the Board at some time during the first quarter of 2019.

The Reporting Persons purchased the Shares for investment in the ordinary course of their investment activities based on the Reporting Persons’ belief that the Shares, when purchased, were undervalued and represented an attractive investment opportunity. The Reporting Persons intend to review their investment in the Issuer on a continuing basis. Depending on various factors including, without limitation, the Issuer’s financial position, the price levels of the Shares, conditions in the securities markets and general economic and industry conditions, the Reporting Persons may in the future take such actions with respect to their investment in the Issuer as they deem appropriate including, without limitation, participating on the Board, engaging in communications with management and/or the Board, engaging in discussions with stockholders of the Issuer and others about the Issuer and the Reporting Persons’ investment, reshaping the Issuer's corporate strategy, recommending business development transactions, proposing changes to management, operations and the structure of the Board (including the composition of the Board), purchasing additional Shares, selling some or all of their Shares, engaging in short selling of or any hedging or similar transaction with respect to the Shares, or changing their intention with respect to any and all matters referred to in subparagraphs (a) - (j) of Item 4 of Schedule 13D.

Except as otherwise set forth herein, the Reporting Persons do not have any present plans or proposals which would relate to, or result in, the matters set forth in subparagraphs (a) – (j) of Item 4 of Schedule 13D. However, subject to market conditions and in compliance with applicable securities laws, the Reporting Persons reserve the right, at a later date, to effect one or more of such changes or transactions in the number of Shares they may be deemed to beneficially own in open-market or privately negotiated transactions, on such terms and at such times as the Reporting Persons may deem advisable.

As of the date hereof, each of the Reporting Persons may be deemed to be the beneficial owner of 2,000,000 Shares, constituting 16.1% of the Shares, based upon 12,390,435 Shares outstanding as of the date hereof. Each of the Reporting Persons has the sole power to vote or direct the vote of 0 Shares and the shared power to vote or direct the vote of 2,000,000 Shares. Each of the Reporting Persons has the sole power to dispose or direct the disposition of 0 Shares and the shared power to dispose or direct the disposition of 2,000,000 Shares.

Other than the transactions described in Item 4 above, there have been no transactions in the Shares by the Reporting Persons during the past sixty days.

(e)

N/A

In addition to the Shares beneficially owned by the Reporting Persons as reported herein, the Master Fund currently holds 4,229,387 currently exercisable warrants of the Issuer, subject to blocker provisions that prevent the Master Fund from exercising the warrants if it would be more than a 4.99% beneficial owner of the Shares following any such exercise.

The information set forth in Item 4 above is also incorporated by reference in its entirety in this Item 6. The Reporting Persons do not have any contract, arrangement, understanding or relationship with any person with respect to securities of the Issuer that is not described in this Item 6, Item 4 above and/or incorporated herein by reference.

Name: Steven Boyd

Title: Managing Member

Name: Steven Boyd

Title: Director

Name: Steven Boyd

Title: Managing Member

Name: Steven Boyd

Title: Director